Assay Detail
Binding
CHEMBL752277
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory constant for the inhibition of human Neuronal nitric oxide synthase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Conformationally restricted arginine analogues as inhibitors of human nitric oxide synthase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.68 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11471 | L-NIO | — | 1 | 6.64 |
| CHEMBL298404 | — | — | 1 | 6.43 |
| CHEMBL49881 | — | — | 1 | 6.39 |
| CHEMBL256147 | TILARGININE | 3.0 | 1 | 6.08 |
| CHEMBL52280 | — | — | 1 | 5.89 |
| CHEMBL48861 | — | — | 1 | 5.08 |
| CHEMBL49010 | — | — | 1 | 4.54 |
| CHEMBL49934 | — | — | 1 | 4.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11471 | L-NIO | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL298404 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL49881 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL256147 | TILARGININE | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL52280 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL48861 | — | Ki | = | 8400.0 | nM | 5.08 |
| CHEMBL49010 | — | Ki | = | 29000.0 | nM | 4.54 |
| CHEMBL49934 | — | Ki | = | 44000.0 | nM | 4.36 |