Assay Detail
Binding
CHEMBL752310
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested for inhibition of [3H]NMS binding against muscarinic acetylcholine receptor in rat brain
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Synthesis, molecular modeling studies, and muscarinic receptor activity of azaprophen analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.74 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL517712 | ATROPINE | 4.0 | 1 | 9.52 |
| CHEMBL550 | PILOCARPINE | 4.0 | 1 | 5.96 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 4.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL517712 | ATROPINE | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL550 | PILOCARPINE | Ki | = | 1110.0 | nM | 5.96 |
| CHEMBL14 | CARBACHOL | Ki | = | 18800.0 | nM | 4.73 |