Assay Detail
Binding
CHEMBL752313
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Inhibition of [3H]OXO-M binding against muscarinic acetylcholine receptor in rat brain membranes
12
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Synthesis, molecular modeling studies, and muscarinic receptor activity of azaprophen analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.05 | 9.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL517712 | ATROPINE | 4.0 | 1 | 9.34 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 7.88 |
| CHEMBL550 | PILOCARPINE | 4.0 | 1 | 7.08 |
| CHEMBL326453 | — | — | 1 | 6.95 |
| CHEMBL111529 | — | — | 2 | 5.94 |
| CHEMBL607175 | — | — | 1 | 5.71 |
| CHEMBL2113669 | — | — | 2 | 5.38 |
| CHEMBL325322 | — | — | 3 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL517712 | ATROPINE | Ki | = | 0.459 | nM | 9.34 |
| CHEMBL14 | CARBACHOL | Ki | = | 13.1 | nM | 7.88 |
| CHEMBL550 | PILOCARPINE | Ki | = | 82.9 | nM | 7.08 |
| CHEMBL326453 | — | Ki | = | 113.0 | nM | 6.95 |
| CHEMBL111529 | — | Ki | = | 1150.0 | nM | 5.94 |
| CHEMBL607175 | — | Ki | = | 1950.0 | nM | 5.71 |
| CHEMBL2113669 | — | Ki | = | 4150.0 | nM | 5.38 |
| CHEMBL111529 | — | Ki | = | 6550.0 | nM | 5.18 |
| CHEMBL325322 | — | Ki | = | 7820.0 | nM | 5.11 |
| CHEMBL325322 | — | Ki | = | 10400.0 | nM | 4.98 |
| CHEMBL2113669 | — | Ki | = | 23300.0 | nM | 4.63 |
| CHEMBL325322 | — | Ki | = | 33900.0 | nM | 4.47 |