Assay Detail
Binding
CHEMBL752334
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of binding of [3H]glycine to N-methyl-D-aspartate glutamate receptor 1 from crude synaptic membranes prepared from adult rat cerebral cortex.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, NMDA 1 (CHEMBL330) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
(E)-3-(2-(N-phenylcarbamoyl)vinyl)pyrrole-2-carboxylic acid derivatives. A novel class of glycine site antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.88 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31741 | — | — | 1 | 8.70 |
| CHEMBL58663 | — | — | 1 | 8.22 |
| CHEMBL287327 | — | — | 1 | 8.11 |
| CHEMBL114610 | — | — | 1 | 7.89 |
| CHEMBL22895 | — | — | 1 | 7.50 |
| CHEMBL31344 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31741 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL58663 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL287327 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL114610 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL22895 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL31344 | — | IC50 | = | 140.0 | nM | 6.85 |