Compound Detail
CHEMBL58663
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Basic Information
| ChEMBL ID | CHEMBL58663 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MCDUTXFQVFQCEV-CVEARBPZSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
406.3
MW (Da)
4.25
ALogP
3
HBA
2
HBD
72.9
PSA (Ų)
0.80
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 1 CHEMBL330 | IC50 | 8.22 | 8.22 | 6.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 1 | IC50 | = | 6.0 | nM | 8.22 | Inhibition of binding of [3H]glycine to N-methyl-D-aspartate glutamate receptor ... | 9526557 |
| Glutamate receptor ionotropic, NMDA 1 | IC50 | = | 6.0 | nM | 8.22 | Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes... | 1534584 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9526557 | 10.1021/jm970416w | Glutamate receptor ionotropic, NMDA 1 | 1 |
| 1534584 | 10.1021/jm00089a004 | Glutamate receptor ionotropic, NMDA 1 | 1 |
| 1534584 | 10.1021/jm00089a004 | Glutamate NMDA receptor | 1 |
Data from ChEMBL 36 via Core Engine