Assay Detail
Functional
CHEMBL752364
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria
4
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological activity of some 4-DAMP- related compounds
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 8.41 | 8.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL306182 | — | — | 1 | 8.91 |
| CHEMBL76897 | 4-DAMP | — | 1 | 8.57 |
| CHEMBL292857 | — | — | 2 | 8.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL306182 | — | Kd | = | 1.23 | nM | 8.91 |
| CHEMBL76897 | 4-DAMP | Kd | = | 2.692 | nM | 8.57 |
| CHEMBL292857 | — | Kd | = | 4.169 | nM | 8.38 |
| CHEMBL292857 | — | Kd | = | 17.38 | nM | 7.76 |