Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL752467

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of [3H]DCKA binding to N-methyl-D-aspartate glutamate receptor
ChEMBL ↗
88
Total Activities
86
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Glutamate [NMDA] receptor (CHEMBL2094124) ↗
Type PROTEIN COMPLEX GROUP
Organism Homo sapiens

Publication

CoMFA and homology-based models of the glycine binding site of N-methyl-d-aspartate receptor.
Tikhonova IG, Baskin II, Palyulin VA, Zefirov NS.
J Med Chem (2003) 46 : 1609 -1616
PubMed 12699379 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 88 6.04 8.33

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL297881 — — 1 8.33
CHEMBL289832 LICOSTINEL 2.0 1 8.23
CHEMBL288855 — — 1 8.15
CHEMBL42426 — — 1 8.06
CHEMBL40623 — — 1 7.92
CHEMBL40976 — — 1 7.64
CHEMBL40652 — — 1 7.54
CHEMBL41460 — — 1 7.54
CHEMBL43846 — — 1 7.52
CHEMBL42915 — — 1 7.48
CHEMBL42146 — — 1 7.43
CHEMBL41691 — — 1 7.35
CHEMBL295154 — — 1 7.28
CHEMBL42248 — — 1 7.19
CHEMBL288839 — — 1 7.14
CHEMBL291149 — — 1 7.09
CHEMBL291148 — — 1 7.02
CHEMBL41291 — — 1 6.96
CHEMBL40745 — — 1 6.89
CHEMBL284028 2,3-DIHYDROXY-6,7-DICHLOROQUINOXALINE — 2 6.89
CHEMBL42466 — — 1 6.82
CHEMBL295995 — — 1 6.82
CHEMBL41295 — — 1 6.80
CHEMBL40708 — — 1 6.77
CHEMBL291161 — — 1 6.66
CHEMBL42176 — — 1 6.66
CHEMBL282003 — — 1 6.55
CHEMBL41340 — — 1 6.54
CHEMBL41341 — — 1 6.40
CHEMBL42329 — — 1 6.20

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL297881 — IC50 = 4.7 nM 8.33
CHEMBL289832 LICOSTINEL IC50 = 5.9 nM 8.23
CHEMBL288855 — IC50 = 7.0 nM 8.15
CHEMBL42426 — IC50 = 8.7 nM 8.06
CHEMBL40623 — IC50 = 12.0 nM 7.92
CHEMBL40976 — IC50 = 23.0 nM 7.64
CHEMBL40652 — IC50 = 29.0 nM 7.54
CHEMBL41460 — IC50 = 29.0 nM 7.54
CHEMBL43846 — IC50 = 30.0 nM 7.52
CHEMBL42915 — IC50 = 33.0 nM 7.48
CHEMBL42146 — IC50 = 37.0 nM 7.43
CHEMBL41691 — IC50 = 45.0 nM 7.35
CHEMBL295154 — IC50 = 53.0 nM 7.28
CHEMBL42248 — IC50 = 64.0 nM 7.19
CHEMBL288839 — IC50 = 73.0 nM 7.14
CHEMBL291149 — IC50 = 82.0 nM 7.09
CHEMBL291148 — IC50 = 95.0 nM 7.02
CHEMBL41291 — IC50 = 110.0 nM 6.96
CHEMBL284028 2,3-DIHYDROXY-6,7-DICHLOROQUINOXALINE IC50 = 130.0 nM 6.89
CHEMBL284028 2,3-DIHYDROXY-6,7-DICHLOROQUINOXALINE IC50 = 130.0 nM 6.89
CHEMBL40745 — IC50 = 130.0 nM 6.89
CHEMBL42466 — IC50 = 150.0 nM 6.82
CHEMBL295995 — IC50 = 150.0 nM 6.82
CHEMBL41295 — IC50 = 160.0 nM 6.80
CHEMBL40708 — IC50 = 170.0 nM 6.77
CHEMBL42176 — IC50 = 220.0 nM 6.66
CHEMBL291161 — IC50 = 220.0 nM 6.66
CHEMBL282003 — IC50 = 280.0 nM 6.55
CHEMBL41340 — IC50 = 290.0 nM 6.54
CHEMBL41341 — IC50 = 400.0 nM 6.40
CHEMBL42329 — IC50 = 630.0 nM 6.20
CHEMBL41399 — IC50 = 640.0 nM 6.19
CHEMBL289779 — IC50 = 730.0 nM 6.14
CHEMBL288384 — IC50 = 780.0 nM 6.11
CHEMBL291169 — IC50 = 910.0 nM 6.04
CHEMBL553334 — IC50 = 1000.0 nM 6.00
CHEMBL42071 — IC50 = 1400.0 nM 5.85
CHEMBL42482 — IC50 = 1400.0 nM 5.85
CHEMBL42350 — IC50 = 1500.0 nM 5.82
CHEMBL295178 — IC50 = 1500.0 nM 5.82
CHEMBL44260 — IC50 = 1800.0 nM 5.75
CHEMBL21641 — IC50 = 1800.0 nM 5.75
CHEMBL42694 — IC50 = 1800.0 nM 5.75
CHEMBL40649 — IC50 = 1900.0 nM 5.72
CHEMBL296068 — IC50 = 2100.0 nM 5.68
CHEMBL290747 — IC50 = 2800.0 nM 5.55
CHEMBL297310 — IC50 = 2900.0 nM 5.54
CHEMBL41180 — IC50 = 3000.0 nM 5.52
CHEMBL296521 — IC50 = 3100.0 nM 5.51
CHEMBL295084 — IC50 = 3300.0 nM 5.48