Compound Detail
CHEMBL40623
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Basic Information
| ChEMBL ID | CHEMBL40623 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WCNOWXRSBULRSP-UHFFFAOYSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
259.1
MW (Da)
3.35
ALogP
5
HBA
2
HBD
82.8
PSA (Ų)
0.77
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate NMDA receptor CHEMBL1907608 | IC50 | 7.92 | 7.92 | 12.0 | 1 |
| Glutamate [NMDA] receptor CHEMBL2094124 | IC50 | 7.92 | 7.92 | 12.0 | 1 |
| Glutamate receptor ionotropic, NMDA 1 CHEMBL330 | IC50 | 7.92 | 7.92 | 12.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate NMDA receptor | IC50 | = | 12.0 | nM | 7.92 | Inhibition of [3H]DCKA binding to NMDA receptor of rat brain membranes. | 8917657 |
| Glutamate [NMDA] receptor | IC50 | = | 12.0 | nM | 7.92 | Inhibition of [3H]DCKA binding to N-methyl-D-aspartate glutamate receptor | 12699379 |
| Glutamate receptor ionotropic, NMDA 1 | IC50 | = | 12.0 | nM | 7.92 | Inhibition of [3H]- DCKA binding to NMDA receptor of rat brain membranes | 8765507 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12699379 | 10.1021/jm0210156 | Glutamate [NMDA] receptor | 2 |
| 8765507 | 10.1021/jm960214k | Unchecked | 2 |
| 8917657 | 10.1021/jm960520y | Glutamate NMDA receptor | 1 |
| 8765507 | 10.1021/jm960214k | Glutamate receptor ionotropic, NMDA 1 | 1 |
| 8765507 | 10.1021/jm960214k | Glutamate receptor ionotropic, AMPA | 1 |
Data from ChEMBL 36 via Core Engine