Assay Detail
Binding
CHEMBL745939
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]DCKA binding to NMDA receptor of rat brain membranes.
32
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Structure-activity relationships of 4-hydroxy-3-nitroquinolin-2(1H)-ones as novel antagonists at the glycine site of N-methyl-D-aspartate receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 6.29 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288855 | — | — | 1 | 8.15 |
| CHEMBL40623 | — | — | 1 | 7.92 |
| CHEMBL291161 | — | — | 1 | 7.66 |
| CHEMBL43846 | — | — | 2 | 7.52 |
| CHEMBL42915 | — | — | 1 | 7.48 |
| CHEMBL42146 | — | — | 1 | 7.43 |
| CHEMBL295154 | — | — | 1 | 7.28 |
| CHEMBL284028 | 2,3-DIHYDROXY-6,7-DICHLOROQUINOXALINE | — | 1 | 6.89 |
| CHEMBL42176 | — | — | 1 | 6.66 |
| CHEMBL282003 | — | — | 1 | 6.55 |
| CHEMBL41340 | — | — | 1 | 6.54 |
| CHEMBL41341 | — | — | 1 | 6.40 |
| CHEMBL42329 | — | — | 1 | 6.20 |
| CHEMBL289779 | — | — | 1 | 6.14 |
| CHEMBL291169 | — | — | 1 | 6.04 |
| CHEMBL42071 | — | — | 1 | 5.85 |
| CHEMBL21641 | — | — | 2 | 5.75 |
| CHEMBL296068 | — | — | 1 | 5.68 |
| CHEMBL291170 | — | — | 1 | 5.48 |
| CHEMBL43318 | — | — | 1 | 5.47 |
| CHEMBL42057 | — | — | 1 | 5.36 |
| CHEMBL282672 | — | — | 1 | 5.01 |
| CHEMBL296577 | — | — | 1 | 4.47 |
| CHEMBL298232 | — | — | 1 | 4.40 |
| CHEMBL288904 | — | — | 1 | 4.21 |
| CHEMBL44079 | — | — | 1 | - |
| CHEMBL41538 | — | — | 1 | - |
| CHEMBL296558 | — | — | 1 | - |
| CHEMBL295179 | — | — | 1 | - |
| CHEMBL43918 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288855 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL40623 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL291161 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL43846 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL43846 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL42915 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL42146 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL295154 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL284028 | 2,3-DIHYDROXY-6,7-DICHLOROQUINOXALINE | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL42176 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL282003 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL41340 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL41341 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL42329 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL289779 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL291169 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL42071 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL21641 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL21641 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL296068 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL291170 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL43318 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL42057 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL282672 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL296577 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL298232 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL288904 | — | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL41538 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL44079 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL296558 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL295179 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL43918 | — | IC50 | > | 100000.0 | nM | - |