Assay Detail
Binding
CHEMBL752501
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability of compound to displace [3H]glycine from N-methyl-D-aspartate glutamate receptor 1 from in cerebral cortex synaptic membranes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, NMDA 1 (CHEMBL330) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
3-hydroxy-quinazoline-2,4-dione as a useful scaffold to obtain selective Gly/NMDA and AMPA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.90 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307267 | — | — | 1 | 6.70 |
| CHEMBL80594 | — | — | 1 | 6.62 |
| CHEMBL77569 | — | — | 1 | 6.52 |
| CHEMBL432748 | — | — | 1 | 5.96 |
| CHEMBL311831 | — | — | 1 | 4.97 |
| CHEMBL77362 | — | — | 1 | 4.64 |
| CHEMBL310286 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307267 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL80594 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL77569 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL432748 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL311831 | — | Ki | = | 10600.0 | nM | 4.97 |
| CHEMBL77362 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL310286 | — | Ki | > | 100000.0 | nM | - |