Compound Detail
CHEMBL77362
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Basic Information
| ChEMBL ID | CHEMBL77362 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SEFAZKVWQRDGAL-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
307.1
MW (Da)
2.99
ALogP
3
HBA
1
HBD
54.9
PSA (Ų)
0.75
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 4.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 1 CHEMBL330 | Ki | 4.64 | 4.64 | 23000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 1 | Ki | = | 23000.0 | nM | 4.64 | Ability of compound to displace [3H]glycine from N-methyl-D-aspartate glutamate ... | 15081038 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15081038 | 10.1016/j.bmcl.2004.01.109 | Glutamate receptor ionotropic, NMDA 1 | 1 |
| 15081038 | 10.1016/j.bmcl.2004.01.109 | Glutamate receptor ionotropic, AMPA | 1 |
| 15081038 | 10.1016/j.bmcl.2004.01.109 | Glutamate receptor ionotropic, kainate | 1 |
Data from ChEMBL 36 via Core Engine