Assay Detail
Binding
CHEMBL752503
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Binding selectivity towards N-methyl-D-aspartate glutamate receptor 1 was determined by using [3H]- glycine/NMDA
55
Total Activities
54
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Glutamate receptor ionotropic, NMDA 1 (CHEMBL330) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Selectivity fields: comparative molecular field analysis (CoMFA) of the glycine/NMDA and AMPA receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 55 | 5.43 | 7.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274588 | — | — | 1 | 7.13 |
| CHEMBL311221 | — | — | 1 | 6.85 |
| CHEMBL131309 | — | — | 1 | 6.80 |
| CHEMBL83551 | — | — | 1 | 6.77 |
| CHEMBL8693 | — | — | 1 | 6.72 |
| CHEMBL275106 | — | — | 1 | 6.62 |
| CHEMBL82050 | — | — | 1 | 6.41 |
| CHEMBL8995 | — | — | 1 | 6.32 |
| CHEMBL84283 | — | — | 1 | 6.24 |
| CHEMBL420392 | — | — | 1 | 6.15 |
| CHEMBL81874 | — | — | 1 | 6.15 |
| CHEMBL322916 | — | — | 2 | 6.07 |
| CHEMBL450008 | — | — | 1 | 5.96 |
| CHEMBL310352 | — | — | 1 | 5.96 |
| CHEMBL309441 | — | — | 1 | 5.96 |
| CHEMBL79505 | — | — | 1 | 5.96 |
| CHEMBL8910 | — | — | 1 | 5.85 |
| CHEMBL79556 | — | — | 1 | 5.75 |
| CHEMBL8992 | — | — | 1 | 5.70 |
| CHEMBL310014 | — | — | 1 | 5.66 |
| CHEMBL81025 | — | — | 1 | 5.58 |
| CHEMBL83919 | — | — | 1 | 5.52 |
| CHEMBL79312 | — | — | 1 | 5.46 |
| CHEMBL432781 | — | — | 1 | 5.44 |
| CHEMBL267504 | — | — | 1 | 5.40 |
| CHEMBL83322 | — | — | 1 | 5.35 |
| CHEMBL106088 | — | — | 1 | 5.32 |
| CHEMBL128824 | — | — | 1 | 5.32 |
| CHEMBL81367 | — | — | 1 | 5.29 |
| CHEMBL83901 | — | — | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274588 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL311221 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL131309 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL83551 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL8693 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL275106 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL82050 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL8995 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL84283 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL420392 | — | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL81874 | — | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL322916 | — | Ki | = | 860.0 | nM | 6.07 |
| CHEMBL310352 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL450008 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL309441 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL79505 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL8910 | — | Ki | = | 1410.0 | nM | 5.85 |
| CHEMBL79556 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL8992 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL310014 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL81025 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL83919 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL79312 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL432781 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL267504 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL83322 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL128824 | — | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL106088 | — | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL81367 | — | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL322916 | — | Ki | = | 5300.0 | nM | 5.28 |
| CHEMBL83901 | — | Ki | = | 5400.0 | nM | 5.27 |
| CHEMBL82684 | — | Ki | = | 6500.0 | nM | 5.19 |
| CHEMBL82295 | — | Ki | = | 7200.0 | nM | 5.14 |
| CHEMBL309206 | — | Ki | = | 7500.0 | nM | 5.12 |
| CHEMBL131614 | — | Ki | = | 8200.0 | nM | 5.09 |
| CHEMBL131766 | — | Ki | = | 8300.0 | nM | 5.08 |
| CHEMBL313269 | — | Ki | = | 8800.0 | nM | 5.06 |
| CHEMBL83446 | — | Ki | = | 9600.0 | nM | 5.02 |
| CHEMBL84094 | — | Ki | = | 9700.0 | nM | 5.01 |
| CHEMBL325988 | — | Ki | = | 10240.0 | nM | 4.99 |
| CHEMBL131258 | — | Ki | = | 10600.0 | nM | 4.97 |
| CHEMBL9037 | — | Ki | = | 10600.0 | nM | 4.97 |
| CHEMBL86164 | — | Ki | = | 16700.0 | nM | 4.78 |
| CHEMBL131012 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL326678 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL9253 | — | Ki | = | 26500.0 | nM | 4.58 |
| CHEMBL83902 | — | Ki | = | 27700.0 | nM | 4.56 |
| CHEMBL341209 | — | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL8967 | — | Ki | = | 33300.0 | nM | 4.48 |
| CHEMBL320952 | — | Ki | = | 33500.0 | nM | 4.47 |