Compound Detail
CHEMBL326678
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Basic Information
| ChEMBL ID | CHEMBL326678 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CIEHTSSITKZVPS-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
358.8
MW (Da)
2.00
ALogP
9
HBA
1
HBD
107.4
PSA (Ų)
0.56
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 5.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, kainate CHEMBL2094119 | Ki | 5.15 | 5.15 | 7100.0 | 1 |
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | Ki | 4.74 | 4.74 | 18400.0 | 1 |
| Glutamate receptor ionotropic, NMDA 1 CHEMBL330 | Ki | 4.64 | 4.64 | 23000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, kainate | Ki | = | 7100.0 | nM | 5.15 | Inhibition of specific binding of [3H]KA at kainate receptor in rat brain membra... | 11543685 |
| Glutamate receptor ionotropic, AMPA | Ki | = | 18400.0 | nM | 4.74 | Binding selectivity towards Ionotropic glutamate receptor AMPA was determined by... | 12954059 |
| Glutamate receptor ionotropic, NMDA 1 | Ki | = | 23000.0 | nM | 4.64 | Binding selectivity towards N-methyl-D-aspartate glutamate receptor 1 was determ... | 12954059 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11543685 | 10.1021/jm010862q | Glutamate receptor ionotropic, kainate | 2 |
| 12954059 | 10.1021/jm030833a | Glutamate receptor ionotropic, AMPA | 1 |
| 12954059 | 10.1021/jm030833a | Glutamate receptor ionotropic, NMDA 1 | 1 |
| 11543685 | 10.1021/jm010862q | Glutamate receptor ionotropic, AMPA | 1 |
Data from ChEMBL 36 via Core Engine