Assay Detail
Binding
CHEMBL701300
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of specific binding of [3H]KA at kainate receptor in rat brain membranes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, kainate (CHEMBL2094119) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis, ionotropic glutamate receptor binding affinity, and structure-activity relationships of a new set of 4,5-dihydro-8-heteroaryl-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates analogues of TQX-173.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.15 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL310014 | — | — | 1 | 5.66 |
| CHEMBL326678 | — | — | 1 | 5.15 |
| CHEMBL110497 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL310014 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL326678 | — | Ki | = | 7100.0 | nM | 5.15 |
| CHEMBL110497 | — | Ki | = | 23000.0 | nM | 4.64 |