Compound Detail
CHEMBL110497
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL110497 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FGBOCGAADXOJPF-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
357.8
MW (Da)
2.60
ALogP
8
HBA
1
HBD
94.5
PSA (Ų)
0.57
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 4.74
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | Ki | 4.74 | 4.74 | 18400.0 | 1 |
| Glutamate receptor ionotropic, kainate CHEMBL2094119 | Ki | 4.64 | 4.64 | 23000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA | Ki | = | 18400.0 | nM | 4.74 | Binding affinity at ionotropic glutamate receptor AMPA in rat cortical membranes... | 11543685 |
| Glutamate receptor ionotropic, kainate | Ki | = | 23000.0 | nM | 4.64 | Inhibition of specific binding of [3H]KA at kainate receptor in rat brain membra... | 11543685 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11543685 | 10.1021/jm010862q | Glutamate receptor ionotropic, kainate | 2 |
| 11543685 | 10.1021/jm010862q | Glutamate receptor ionotropic, AMPA | 1 |
Data from ChEMBL 36 via Core Engine