Assay Detail
Binding
CHEMBL752507
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In vitro inhibition of rat neutral endopeptidase
32
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potent and selective non-peptidic inhibitors of endothelin-converting enzyme-1 with sustained duration of action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 6.18 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290698 | — | — | 1 | 9.00 |
| CHEMBL147157 | — | — | 1 | 8.57 |
| CHEMBL10247 | THIORPHAN | -1.0 | 1 | 8.32 |
| CHEMBL285619 | — | — | 1 | 8.30 |
| CHEMBL413724 | — | — | 1 | 7.92 |
| CHEMBL40028 | — | — | 1 | 7.85 |
| CHEMBL479579 | PHOSPHORAMIDON | — | 1 | 7.52 |
| CHEMBL357226 | — | — | 1 | 7.51 |
| CHEMBL148056 | — | — | 1 | 6.94 |
| CHEMBL147041 | — | — | 1 | 6.85 |
| CHEMBL147964 | — | — | 2 | 6.68 |
| CHEMBL147163 | — | — | 1 | 6.64 |
| CHEMBL343904 | — | — | 1 | 6.35 |
| CHEMBL359437 | — | — | 1 | 5.79 |
| CHEMBL146936 | — | — | 1 | 5.64 |
| CHEMBL147847 | — | — | 1 | 5.24 |
| CHEMBL423751 | — | — | 2 | 5.19 |
| CHEMBL289150 | — | — | 1 | 5.17 |
| CHEMBL357251 | — | — | 1 | 4.86 |
| CHEMBL358098 | — | — | 1 | 4.82 |
| CHEMBL342962 | — | — | 1 | 4.75 |
| CHEMBL342077 | — | — | 2 | 4.55 |
| CHEMBL359024 | — | — | 2 | 4.32 |
| CHEMBL148232 | — | — | 1 | - |
| CHEMBL357441 | — | — | 1 | - |
| CHEMBL358774 | — | — | 1 | - |
| CHEMBL145943 | — | — | 1 | - |
| CHEMBL147730 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290698 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL147157 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL10247 | THIORPHAN | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL285619 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL413724 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL40028 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL479579 | PHOSPHORAMIDON | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL357226 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL148056 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL147041 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL147964 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL147163 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL343904 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL359437 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL146936 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL147847 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL423751 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL289150 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL147964 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL357251 | — | IC50 | = | 13770.0 | nM | 4.86 |
| CHEMBL358098 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL342962 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL423751 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL342077 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL342077 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL359024 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL359024 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL148232 | — | IC50 | > | 16000.0 | nM | - |
| CHEMBL357441 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL358774 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL145943 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL147730 | — | IC50 | > | 10000.0 | nM | - |