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Assay Detail

CHEMBL752554

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cell growth inhibition against NUGC3 human stomach cancer cells using MTS assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type Cancer cell lines
Confidence 3 — Cell-line / Tissue
Curated By Autocuration

Publication

Synthesis and structure-activity relationship of 2-aminobenzophenone derivatives as antimitotic agents.
Liou JP, Chang CW, Song JS, Yang YN, Yeh CF, Tseng HY, Lo YK, Chang YL, Chang CM, Hsieh HP.
J Med Chem (2002) 45 : 2556 -2562
PubMed 12036364 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 6.04 7.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL9011 1 7.30
CHEMBL9309 1 7.10
CHEMBL82914 1 6.31
CHEMBL85014 1 6.30
CHEMBL431388 1 6.28
CHEMBL86016 1 6.27
CHEMBL86236 1 6.27
CHEMBL315222 1 6.26
CHEMBL87016 1 6.25
CHEMBL82915 1 5.43
CHEMBL83586 1 5.36
CHEMBL87464 1 5.30
CHEMBL67 COMBRETASTATIN A4 -1.0 1 5.07
CHEMBL276625 PHENSTATIN 1 5.01
CHEMBL87695 1 -
CHEMBL85642 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL9011 IC50 = 50.0 nM 7.30
CHEMBL9309 IC50 = 80.0 nM 7.10
CHEMBL82914 IC50 = 485.0 nM 6.31
CHEMBL85014 IC50 = 500.0 nM 6.30
CHEMBL431388 IC50 = 523.0 nM 6.28
CHEMBL86016 IC50 = 534.0 nM 6.27
CHEMBL86236 IC50 = 537.0 nM 6.27
CHEMBL315222 IC50 = 544.0 nM 6.26
CHEMBL87016 IC50 = 563.0 nM 6.25
CHEMBL82915 IC50 = 3679.0 nM 5.43
CHEMBL83586 IC50 = 4407.0 nM 5.36
CHEMBL87464 IC50 = 5019.0 nM 5.30
CHEMBL67 COMBRETASTATIN A4 IC50 = 8520.0 nM 5.07
CHEMBL276625 PHENSTATIN IC50 = 9754.0 nM 5.01
CHEMBL87695 IC50 > 10000.0 nM -
CHEMBL85642 IC50 > 10000.0 nM -