Assay Detail
Binding
CHEMBL752562
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding of [3H]batrachotoxin (BTX) to rat brain sodium channel
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Sodium channel alpha subunits; brain (Types I, II, III) (CHEMBL2095171) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Synthesis and preliminary biological evaluation of new alpha-amino amide anticonvulsants incorporating a dextromethorphan moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.46 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL22207 | RACEMETHORPHAN | 2.0 | 1 | 5.89 |
| CHEMBL51777 | — | — | 1 | 5.58 |
| CHEMBL52539 | — | — | 1 | 5.28 |
| CHEMBL48582 | SAFINAMIDE MESYLATE | 4.0 | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL22207 | RACEMETHORPHAN | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL51777 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL52539 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL48582 | SAFINAMIDE MESYLATE | IC50 | = | 8200.0 | nM | 5.09 |