Assay Detail
Binding
CHEMBL752593
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Inhibition of [3H]U-69593 radioligand binding to Guinea pig opioid receptor kappa 1.
28
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Probes for narcotic receptor-mediated phenomena. 20. Alteration of opioid receptor subtype selectivity of the 5-(3-hydroxyphenyl)morphans by application of the message-address concept: preparation of delta-opioid receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.20 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70 | MORPHINE | 4.0 | 1 | 8.74 |
| CHEMBL38961 | — | — | 1 | 7.05 |
| CHEMBL290095 | — | — | 1 | 6.71 |
| CHEMBL37584 | — | — | 1 | 6.62 |
| CHEMBL434203 | — | — | 1 | 6.10 |
| CHEMBL285250 | — | — | 2 | 6.09 |
| CHEMBL38086 | — | — | 1 | 6.03 |
| CHEMBL38791 | — | — | 3 | 6.01 |
| CHEMBL288495 | — | — | 1 | 6.00 |
| CHEMBL436351 | — | — | 1 | 5.67 |
| CHEMBL430732 | — | — | 1 | 5.65 |
| CHEMBL39886 | — | — | 1 | 5.25 |
| CHEMBL288730 | — | — | 1 | - |
| CHEMBL39994 | — | — | 1 | - |
| CHEMBL39319 | — | — | 1 | - |
| CHEMBL40188 | — | — | 1 | - |
| CHEMBL39531 | — | — | 1 | - |
| CHEMBL290557 | — | — | 1 | - |
| CHEMBL290301 | — | — | 1 | - |
| CHEMBL288803 | — | — | 3 | - |
| CHEMBL288669 | — | — | 1 | - |
| CHEMBL289157 | — | — | 1 | - |
| CHEMBL288729 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70 | MORPHINE | IC50 | = | 1.82 | nM | 8.74 |
| CHEMBL38961 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL290095 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL37584 | — | IC50 | = | 240.5 | nM | 6.62 |
| CHEMBL434203 | — | IC50 | = | 798.3 | nM | 6.10 |
| CHEMBL285250 | — | IC50 | = | 818.6 | nM | 6.09 |
| CHEMBL285250 | — | IC50 | = | 910.5 | nM | 6.04 |
| CHEMBL38086 | — | IC50 | = | 934.0 | nM | 6.03 |
| CHEMBL38791 | — | IC50 | = | 981.5 | nM | 6.01 |
| CHEMBL288495 | — | IC50 | = | 993.0 | nM | 6.00 |
| CHEMBL38791 | — | IC50 | = | 2025.7 | nM | 5.69 |
| CHEMBL436351 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL430732 | — | IC50 | = | 2216.0 | nM | 5.65 |
| CHEMBL38791 | — | IC50 | = | 5071.0 | nM | 5.29 |
| CHEMBL39886 | — | IC50 | = | 5563.0 | nM | 5.25 |
| CHEMBL40188 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL288730 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL39531 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL39319 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL288803 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL290557 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL290301 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL288803 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL288803 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL39994 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL288669 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL289157 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL288729 | — | IC50 | > | 1000.0 | nM | - |