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Assay Detail

CHEMBL752608

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Functional
Agonistic activity towards Opioid receptor delta 1 was determined by evaluating the inhibitory activity towards electrically stimulated mouse vas deferens
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Tissue Vas deferens
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Delta-type opioid receptor (CHEMBL3222)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Effects of modifications of residues in position 3 of dynorphin A(1-11)-NH2 on kappa receptor selectivity and potency.
Lung FD, Meyer JP, Lou BS, Xiang L, Li G, Davis P, DeLeon IA, Yamamura HI, Porreca F, Hruby VJ.
J Med Chem (1996) 39 : 2456 -2460
PubMed 8691442 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.76 7.59

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL216640 1 7.59
CHEMBL413228 1 6.55
CHEMBL2369902 1 6.17
CHEMBL407303 1 6.14
CHEMBL412792 1 6.13
CHEMBL415224 1 6.00
CHEMBL2369124 1 5.82
CHEMBL2369903 1 5.55
CHEMBL2369901 1 5.52
CHEMBL2369125 1 5.35
CHEMBL438034 1 5.25
CHEMBL414554 1 4.89
CHEMBL2369126 1 4.85
CHEMBL216940 1 4.80
CHEMBL269119 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL216640 IC50 = 25.5 nM 7.59
CHEMBL413228 IC50 = 280.0 nM 6.55
CHEMBL2369902 IC50 = 670.0 nM 6.17
CHEMBL407303 IC50 = 730.0 nM 6.14
CHEMBL412792 IC50 = 740.0 nM 6.13
CHEMBL415224 IC50 = 1000.0 nM 6.00
CHEMBL2369124 IC50 = 1520.0 nM 5.82
CHEMBL2369903 IC50 = 2830.0 nM 5.55
CHEMBL2369901 IC50 = 3040.0 nM 5.52
CHEMBL2369125 IC50 = 4490.0 nM 5.35
CHEMBL438034 IC50 = 5600.0 nM 5.25
CHEMBL414554 IC50 = 13000.0 nM 4.89
CHEMBL2369126 IC50 = 14000.0 nM 4.85
CHEMBL216940 IC50 = 16000.0 nM 4.80
CHEMBL269119 IC50 > 60000.0 nM -