Assay Detail
Binding
CHEMBL752652
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Binding affinity against Opioid receptor kappa 1 using [3H]-U-69,593 as radioligand
11
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of a novel class of substituted pyrrolooctahydroisoquinolines as potent and selective delta opioid agonists, based on an extension of the message-address concept.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.44 | 8.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL567175 | NALTRINDOLE | — | 1 | 8.02 |
| CHEMBL324236 | — | — | 1 | 7.20 |
| CHEMBL401093 | OXYMORPHINDOLE | — | 1 | 7.11 |
| CHEMBL107670 | — | — | 3 | 6.78 |
| CHEMBL108076 | — | — | 1 | 6.30 |
| CHEMBL100729 | — | — | 3 | 5.89 |
| CHEMBL13470 | SNC-80 | — | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL567175 | NALTRINDOLE | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL324236 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL401093 | OXYMORPHINDOLE | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL107670 | — | Ki | = | 167.0 | nM | 6.78 |
| CHEMBL107670 | — | Ki | = | 334.0 | nM | 6.48 |
| CHEMBL108076 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL107670 | — | Ki | = | 771.0 | nM | 6.11 |
| CHEMBL100729 | — | Ki | = | 1298.0 | nM | 5.89 |
| CHEMBL100729 | — | Ki | = | 1340.0 | nM | 5.87 |
| CHEMBL13470 | SNC-80 | Ki | = | 1348.0 | nM | 5.87 |
| CHEMBL100729 | — | Ki | = | 6005.0 | nM | 5.22 |