Assay Detail
Binding
CHEMBL752718
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to inhibit the bound [125I]L-T3 rat liver Nuclear L-triiodothyronine receptor is determined in vitro.
16
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of oxamic acid and acetic acid derivatives related to L-thyronine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 8.51 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL350265 | — | — | 1 | 10.00 |
| CHEMBL289343 | — | — | 1 | 9.96 |
| CHEMBL159682 | AXITIROME | 2.0 | 3 | 9.85 |
| CHEMBL159976 | — | — | 1 | 9.51 |
| CHEMBL163380 | — | — | 1 | 8.96 |
| CHEMBL162692 | — | — | 1 | 8.82 |
| CHEMBL347713 | — | — | 1 | 8.46 |
| CHEMBL352126 | — | — | 1 | 7.92 |
| CHEMBL163611 | — | — | 1 | 7.47 |
| CHEMBL349076 | — | — | 1 | 7.32 |
| CHEMBL160203 | — | — | 1 | 7.24 |
| CHEMBL350930 | — | — | 1 | 6.40 |
| CHEMBL161776 | — | — | 1 | 6.26 |
| CHEMBL163994 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL350265 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL289343 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL159682 | AXITIROME | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL159682 | AXITIROME | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL159682 | AXITIROME | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL159976 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL163380 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL162692 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL347713 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL352126 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL163611 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL349076 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL160203 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL350930 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL161776 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL163994 | — | IC50 | > | 5000.0 | nM | - |