Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL752781

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Agonist activity was evaluated in mouse vas deferens (MVD) preparations at Opioid receptor delta 1
11
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Delta-type opioid receptor (CHEMBL3222)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective delta agonist (+)-4-[(alpha R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N,N-diethylbenzamide (SNC 80) and related novel nonpeptide delta opioid receptor ligands.
Calderon SN, Rice KC, Rothman RB, Porreca F, Flippen-Anderson JL, Kayakiri H, Xu H, Becketts K, Smith LE, Bilsky EJ, Davis P, Horvath R.
J Med Chem (1997) 40 : 695 -704
PubMed 9057856 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 7.58 8.56

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL13470 SNC-80 3 8.56
CHEMBL159618 2 8.01
CHEMBL153648 3 7.98
CHEMBL611159 1 7.51
CHEMBL347712 1 7.35
CHEMBL611160 1 6.90

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL13470 SNC-80 IC50 = 2.73 nM 8.56
CHEMBL13470 SNC-80 IC50 = 5.34 nM 8.27
CHEMBL159618 IC50 = 9.77 nM 8.01
CHEMBL159618 IC50 = 10.25 nM 7.99
CHEMBL153648 IC50 = 10.56 nM 7.98
CHEMBL153648 IC50 = 14.07 nM 7.85
CHEMBL611159 IC50 = 30.89 nM 7.51
CHEMBL347712 IC50 = 44.21 nM 7.35
CHEMBL611160 IC50 = 126.2 nM 6.90
CHEMBL153648 IC50 = 182.4 nM 6.74
CHEMBL13470 SNC-80 IC50 = 646.8 nM 6.19