Assay Detail
Functional
CHEMBL752782
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Antagonist activity against delta-opioid receptor in mouse vas deferens in the presence of DADLE
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Vas deferens |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and delta-opioid receptor antagonist activity of a naltrindole analogue with a regioisomeric indole moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.55 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL291973 | — | — | 1 | 6.00 |
| CHEMBL418105 | — | — | 1 | 5.09 |
| CHEMBL567175 | NALTRINDOLE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL291973 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL418105 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL567175 | NALTRINDOLE | IC50 | = | 459000.0 | nM | - |