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Assay Detail

CHEMBL752791

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of hepatitis C virus (HCV) NS3 protease.
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Hepacivirus hominis
Confidence 7 — Homologous single protein target
Curated By Autocuration

Target

Hepatitis C virus serine protease, NS3/NS4A (CHEMBL2095231)
Type PROTEIN COMPLEX
Organism Hepatitis C virus

Publication

Studies on the C-terminal of hexapeptide inhibitors of the hepatitis C virus serine protease.
Llinàs-Brunet M, Bailey M, Déziel R, Fazal G, Gorys V, Goulet S, Halmos T, Maurice R, Poirier M, Poupart MA, Rancourt J, Thibeault D, Wernic D, Lamarre D.
Bioorg Med Chem Lett (1998) 8 : 2719 -2724
PubMed 9873610 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 4.99 6.19

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2370184 1 6.19
CHEMBL2370193 1 5.96
CHEMBL2370179 1 5.70
CHEMBL2370171 1 5.03
CHEMBL2370196 1 5.00
CHEMBL2370192 1 4.92
CHEMBL306027 1 4.77
CHEMBL2370174 1 4.77
CHEMBL310738 1 4.66
CHEMBL295605 1 4.55
CHEMBL2370189 1 4.28
CHEMBL2370191 1 4.10
CHEMBL2370178 1 -
CHEMBL72695 1 -
CHEMBL2370176 1 -
CHEMBL2370195 1 -
CHEMBL2370187 1 -
CHEMBL2370172 1 -
CHEMBL2370177 1 -
CHEMBL2370188 1 -
CHEMBL2311162 1 -
CHEMBL1790295 1 -
CHEMBL2370173 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2370184 IC50 = 640.0 nM 6.19
CHEMBL2370193 IC50 = 1100.0 nM 5.96
CHEMBL2370179 IC50 = 2000.0 nM 5.70
CHEMBL2370171 IC50 = 9300.0 nM 5.03
CHEMBL2370196 IC50 = 10000.0 nM 5.00
CHEMBL2370192 IC50 = 12000.0 nM 4.92
CHEMBL306027 IC50 = 17000.0 nM 4.77
CHEMBL2370174 IC50 = 17000.0 nM 4.77
CHEMBL310738 IC50 = 22000.0 nM 4.66
CHEMBL295605 IC50 = 28000.0 nM 4.55
CHEMBL2370189 IC50 = 52000.0 nM 4.28
CHEMBL2370191 IC50 = 79000.0 nM 4.10
CHEMBL2370178 IC50 = 250000.0 nM -
CHEMBL72695 IC50 = 150000.0 nM -
CHEMBL2370176 IC50 = 280000.0 nM -
CHEMBL2370195 IC50 = 800000.0 nM -
CHEMBL2370187 IC50 = 190000.0 nM -
CHEMBL2370172 IC50 = 160000.0 nM -
CHEMBL2370177 IC50 = 780000.0 nM -
CHEMBL2370188 IC50 = 500000.0 nM -
CHEMBL2311162 IC50 = 160000.0 nM -
CHEMBL1790295 IC50 = 750000.0 nM -
CHEMBL2370173 IC50 > 1000000.0 nM -