Assay Detail
Binding
CHEMBL752833
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Binding affinity of compound against rat kidney neutral endopeptidase (NEP) was determined
7
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Application of a conformationally restricted Phe-Leu dipeptide mimetic to the design of a combined inhibitor of angiotensin I-converting enzyme and neutral endopeptidase 24.11.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.92 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL78429 | — | — | 2 | 10.15 |
| CHEMBL61512 | (R)-THIORPHAN | — | 1 | 8.70 |
| CHEMBL79564 | — | — | 1 | 8.30 |
| CHEMBL309836 | — | — | 2 | 7.35 |
| CHEMBL309424 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL78429 | — | Ki | = | 0.07 | nM | 10.15 |
| CHEMBL78429 | — | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL61512 | (R)-THIORPHAN | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL79564 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL309836 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL309836 | — | Ki | > | 300.0 | nM | - |
| CHEMBL309424 | — | Ki | > | 10000.0 | nM | - |