Assay Detail
Binding
CHEMBL752834
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DAMGO from Opioid receptor mu 1 of guinea pig brain membranes
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
8-Carboxamidocyclazocine analogues: redefining the structure-activity relationships of 2,6-methano-3-benzazocines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.89 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56585 | CYCLAZOCINE | 2.0 | 1 | 10.00 |
| CHEMBL2368218 | — | — | 1 | 9.77 |
| CHEMBL3085528 | — | — | 1 | 9.49 |
| CHEMBL58646 | — | — | 1 | 9.39 |
| CHEMBL279968 | ETHYLKETOCYCLAZOCINE | — | 1 | 9.11 |
| CHEMBL60869 | — | — | 1 | 8.92 |
| CHEMBL157301 | — | — | 1 | 7.62 |
| CHEMBL160924 | — | — | 1 | 7.35 |
| CHEMBL160677 | — | — | 1 | 7.24 |
| CHEMBL157313 | — | — | 1 | 7.20 |
| CHEMBL2021605 | — | — | 1 | 6.44 |
| CHEMBL154255 | — | — | 1 | 6.27 |
| CHEMBL293103 | — | — | 1 | 6.13 |
| CHEMBL346813 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56585 | CYCLAZOCINE | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL2368218 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL3085528 | — | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL58646 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL279968 | ETHYLKETOCYCLAZOCINE | Ki | = | 0.78 | nM | 9.11 |
| CHEMBL60869 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL157301 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL160924 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL160677 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL157313 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL2021605 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL154255 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL293103 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL346813 | — | Ki | = | 3000.0 | nM | 5.52 |