Assay Detail
Functional
CHEMBL752857
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Compound was evaluated for the affinity of the N-methyl-D-aspartate glutamate receptor at 10 uM, partially antagonized by 5 uM NBQX and fully antagonized by 20 uM NBQX.
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis and pharmacology of a new AMPA-kainate receptor agonist with potent convulsant activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 4.94 | 5.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL125440 | — | — | 1 | 5.27 |
| CHEMBL275040 | KAINIC ACID | 2.0 | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL125440 | — | EC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL275040 | KAINIC ACID | EC50 | = | 25000.0 | nM | 4.60 |