Assay Detail
Binding
CHEMBL752858
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for the inhibition of [3H]norepinephrine binding at N-methyl-D-aspartate glutamate receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
DL-tetrazol-5-ylglycine, a highly potent NMDA agonist: its synthesis and NMDA receptor efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 4.86 | 5.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140784 | — | — | 1 | 5.69 |
| CHEMBL1437288 | — | — | 1 | 4.78 |
| CHEMBL291278 | N-METHYL-D-ASPARTIC ACID (NMDA) | 2.0 | 1 | 4.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140784 | — | EC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL1437288 | — | EC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL291278 | N-METHYL-D-ASPARTIC ACID (NMDA) | EC50 | = | 75000.0 | nM | 4.12 |