Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL752865

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Electrophysiological assays in Xenopus oocytes expressing cloned NMDA receptor (NR1A/2C)
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Cell Type Oocyte
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

1-Hydroxy-1,4-dihydroquinoxaline-2,3-diones: Novel antagonists at NMDA receptor glycine sites
Zheng H, Espitia SA, Ilyin V, Hawkinson JE, Woodward RM, Weber E, Keana JF
Bioorg Med Chem Lett (1996) 6 : 439 -440
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.88 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL43846 1 7.52
CHEMBL136539 1 7.10
CHEMBL137772 1 7.03
CHEMBL284028 2,3-DIHYDROXY-6,7-DICHLOROQUINOXALINE 1 6.89
CHEMBL336811 1 6.68
CHEMBL282003 1 6.55
CHEMBL336017 1 5.89
CHEMBL139060 1 5.75
CHEMBL140296 1 5.68
CHEMBL136638 1 5.60
CHEMBL342820 1 5.60
CHEMBL138941 1 5.57
CHEMBL139314 1 4.72
CHEMBL344041 1 4.70
CHEMBL341587 1 4.60
CHEMBL136763 1 4.27

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL43846 IC50 = 30.0 nM 7.52
CHEMBL136539 IC50 = 80.0 nM 7.10
CHEMBL137772 IC50 = 93.0 nM 7.03
CHEMBL284028 2,3-DIHYDROXY-6,7-DICHLOROQUINOXALINE IC50 = 130.0 nM 6.89
CHEMBL336811 IC50 = 210.0 nM 6.68
CHEMBL282003 IC50 = 280.0 nM 6.55
CHEMBL336017 IC50 = 1300.0 nM 5.89
CHEMBL139060 IC50 = 1800.0 nM 5.75
CHEMBL140296 IC50 = 2100.0 nM 5.68
CHEMBL136638 IC50 = 2500.0 nM 5.60
CHEMBL342820 IC50 = 2500.0 nM 5.60
CHEMBL138941 IC50 = 2700.0 nM 5.57
CHEMBL139314 IC50 = 19000.0 nM 4.72
CHEMBL344041 IC50 = 20000.0 nM 4.70
CHEMBL341587 IC50 = 25000.0 nM 4.60
CHEMBL136763 IC50 = 54000.0 nM 4.27