Assay Detail
Binding
CHEMBL752867
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Ability of compound to inhibit the binding of the channel blocking agent [3H](+)-MK-801 in rat cortical membranes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
3-hydroxy-quinazoline-2,4-dione as a useful scaffold to obtain selective Gly/NMDA and AMPA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.53 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL77569 | — | — | 1 | 6.37 |
| CHEMBL307267 | — | — | 1 | 6.12 |
| CHEMBL432748 | — | — | 1 | 5.77 |
| CHEMBL80594 | — | — | 1 | 5.32 |
| CHEMBL311831 | — | — | 1 | 4.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL77569 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL307267 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL432748 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL80594 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL311831 | — | IC50 | = | 89000.0 | nM | 4.05 |