Assay Detail
Binding
CHEMBL752916
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-MK-801 binding to N-methyl-D-aspartate glutamate receptor of rat brain membranes
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Design, synthesis, and pharmacological evaluation of conformationally constrained analogues of N,N'-diaryl- and N-aryl-N-aralkylguanidines as potent inhibitors of neuronal Na+ channels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.24 | 5.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL28853 | — | — | 1 | 5.61 |
| CHEMBL545504 | — | — | 1 | 5.48 |
| CHEMBL103284 | — | — | 1 | 5.43 |
| CHEMBL544098 | — | — | 1 | 5.42 |
| CHEMBL554684 | — | — | 1 | 5.36 |
| CHEMBL320199 | — | — | 1 | 5.36 |
| CHEMBL103642 | — | — | 1 | 5.21 |
| CHEMBL542445 | — | — | 1 | 4.87 |
| CHEMBL543868 | — | — | 1 | 4.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL28853 | — | Ki | = | 2485.0 | nM | 5.61 |
| CHEMBL545504 | — | Ki | = | 3335.0 | nM | 5.48 |
| CHEMBL103284 | — | Ki | = | 3694.0 | nM | 5.43 |
| CHEMBL544098 | — | Ki | = | 3840.0 | nM | 5.42 |
| CHEMBL554684 | — | Ki | = | 4410.0 | nM | 5.36 |
| CHEMBL320199 | — | Ki | = | 4330.0 | nM | 5.36 |
| CHEMBL103642 | — | Ki | = | 6116.0 | nM | 5.21 |
| CHEMBL542445 | — | Ki | = | 13488.0 | nM | 4.87 |
| CHEMBL543868 | — | Ki | = | 35140.0 | nM | 4.45 |