Assay Detail
Functional
CHEMBL752950
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Inhibition of NIH3T3/PDGF Mouse transfected fibroblasts cell line
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Soluble 2-substituted aminopyrido[2,3-d]pyrimidin-7-yl ureas. Structure-activity relationships against selected tyrosine kinases and exploration of in vitro and in vivo anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.99 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301483 | — | — | 1 | 6.00 |
| CHEMBL57347 | — | — | 1 | 5.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301483 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL57347 | — | IC50 | = | 1080.0 | nM | 5.97 |