Assay Detail
Binding
CHEMBL752954
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Binding affinity was evaluated by measuring the ability to displace [3H]DAMGO radioligand binding from Opioid receptor mu 1 in guinea pig brain membranes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of 14-alkoxymorphinans. 11. 3-Hydroxycyprodime and analogues: opioid antagonist profile in comparison to cyprodime.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.21 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317269 | — | — | 1 | 8.85 |
| CHEMBL105665 | — | — | 1 | 8.21 |
| CHEMBL317030 | — | — | 1 | 8.14 |
| CHEMBL322796 | CYPRODIME | — | 1 | 7.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317269 | — | Ki | = | 1.42 | nM | 8.85 |
| CHEMBL105665 | — | Ki | = | 6.15 | nM | 8.21 |
| CHEMBL317030 | — | Ki | = | 7.29 | nM | 8.14 |
| CHEMBL322796 | CYPRODIME | Ki | = | 23.7 | nM | 7.62 |