Assay Detail
Binding
CHEMBL752956
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Compound was evaluated for binding affinity at Opioid receptor mu 1 in guinea pig brain membranes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
An approach to the design of receptor-type-selective non-peptide antagonists of peptidergic receptors: delta opioid antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.41 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19019 | NALTREXONE | 4.0 | 1 | 9.10 |
| CHEMBL567175 | NALTRINDOLE | — | 1 | 8.42 |
| CHEMBL100940 | NALTRIBEN | — | 1 | 7.72 |
| CHEMBL47545 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19019 | NALTREXONE | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL567175 | NALTRINDOLE | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL100940 | NALTRIBEN | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL47545 | — | Ki | > | 1000.0 | nM | - |