Assay Detail
Functional
CHEMBL753022
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested against Muscarinic acetylcholine receptor M3 expressed in A9 L cell line
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | A9L |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Muscarinic acetylcholine receptor M3 (CHEMBL5105) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Synthesis and biological characterization of 1,4,5,6-tetrahydropyrimidine and 2-amino-3,4,5,6-tetrahydropyridine derivatives as selective m1 agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 5.01 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL277014 | — | — | 1 | 5.96 |
| CHEMBL12378 | — | — | 1 | 5.55 |
| CHEMBL281411 | — | — | 1 | 5.24 |
| CHEMBL416736 | — | — | 1 | 5.00 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 5.00 |
| CHEMBL20835 | ACECLIDINE | 3.0 | 1 | 5.00 |
| CHEMBL22089 | — | — | 1 | 4.96 |
| CHEMBL21536 | XANOMELINE | 4.0 | 1 | 4.96 |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | 4.92 |
| CHEMBL557795 | — | — | 1 | 4.92 |
| CHEMBL553602 | — | — | 1 | 4.85 |
| CHEMBL541398 | — | — | 1 | 4.77 |
| CHEMBL542065 | — | — | 1 | 4.75 |
| CHEMBL538467 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL277014 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL12378 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL281411 | — | EC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL416736 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL14 | CARBACHOL | EC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL20835 | ACECLIDINE | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL22089 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL21536 | XANOMELINE | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL7303 | ARECOLINE | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL557795 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL553602 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL541398 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL542065 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL538467 | — | EC50 | = | 50000.0 | nM | 4.30 |