Assay Detail
Functional
CHEMBL753044
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of veratridine-induced Na+ influx in chinese hamster ovary cells expressing alpha subunit of rat brain type voltage-gated sodium channel type 2
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Cell Type | ovary |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium channel protein type 2 subunit alpha (CHEMBL3399) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and pharmacological evaluation of phenylacetamides as sodium-channel blockers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.19 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL30008 | FLUNARIZINE | 2.0 | 1 | 6.38 |
| CHEMBL92870 | LIDOFLAZINE | 2.0 | 1 | 5.62 |
| CHEMBL282833 | — | — | 1 | 5.57 |
| CHEMBL93106 | — | — | 1 | 5.51 |
| CHEMBL92018 | — | — | 1 | 5.46 |
| CHEMBL313859 | — | — | 1 | 5.44 |
| CHEMBL330049 | — | — | 1 | 5.37 |
| CHEMBL327859 | — | — | 1 | 5.35 |
| CHEMBL92071 | — | — | 1 | 5.24 |
| CHEMBL92977 | — | — | 1 | 5.24 |
| CHEMBL92918 | — | — | 1 | 5.12 |
| CHEMBL93436 | — | — | 1 | 4.92 |
| CHEMBL329245 | — | — | 1 | 4.89 |
| CHEMBL93634 | — | — | 1 | 4.89 |
| CHEMBL91288 | — | — | 1 | 4.54 |
| CHEMBL93838 | — | — | 1 | 4.50 |
| CHEMBL91929 | — | — | 1 | 4.14 |
| CHEMBL93065 | — | — | 1 | - |
| CHEMBL94137 | — | — | 1 | - |
| CHEMBL93271 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL30008 | FLUNARIZINE | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL92870 | LIDOFLAZINE | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL282833 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL93106 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL92018 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL313859 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL330049 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL327859 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL92071 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL92977 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL92918 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL93436 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL329245 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL93634 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL91288 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL93838 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL91929 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL93065 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL94137 | — | IC50 | = | 106000.0 | nM | - |
| CHEMBL93271 | — | IC50 | > | 100000.0 | nM | - |