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Assay Detail

CHEMBL753046

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]ouabain binding from Na+,K+ -ATPase receptor isolated from dog kidney
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Canis lupus familiaris
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Digitalis-like compounds: Synthesis and biological evaluation of 3-(aminoalkylthio) derivatives
Gobbini M, Benicchio A, Padoani G, Torri M, Melloni P
Bioorg Med Chem Lett (1997) 7 : 469 -472
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 6.26 7.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2068957 1 7.50
CHEMBL1453 DIGITOXIGENIN 1 7.20
CHEMBL2068956 1 7.10
CHEMBL2069034 1 7.00
CHEMBL2069018 1 7.00
CHEMBL2068953 1 6.80
CHEMBL2069029 1 6.70
CHEMBL2069009 1 6.60
CHEMBL2069031 1 6.60
CHEMBL2068951 1 6.50
CHEMBL2069020 1 6.50
CHEMBL2069024 1 6.50
CHEMBL1765662 1 6.00
CHEMBL141888 1 5.80
CHEMBL3138266 1 5.80
CHEMBL2069050 1 5.80
CHEMBL2068952 1 5.60
CHEMBL2068955 1 5.60
CHEMBL2069102 1 5.50
CHEMBL142270 1 5.50
CHEMBL3137944 1 5.20
CHEMBL2068954 1 5.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2068957 IC50 = 31.62 nM 7.50
CHEMBL1453 DIGITOXIGENIN IC50 = 63.1 nM 7.20
CHEMBL2068956 IC50 = 79.43 nM 7.10
CHEMBL2069034 IC50 = 100.0 nM 7.00
CHEMBL2069018 IC50 = 100.0 nM 7.00
CHEMBL2068953 IC50 = 158.49 nM 6.80
CHEMBL2069029 IC50 = 199.53 nM 6.70
CHEMBL2069009 IC50 = 251.19 nM 6.60
CHEMBL2069031 IC50 = 251.19 nM 6.60
CHEMBL2068951 IC50 = 316.23 nM 6.50
CHEMBL2069020 IC50 = 316.23 nM 6.50
CHEMBL2069024 IC50 = 316.23 nM 6.50
CHEMBL1765662 IC50 = 1000.0 nM 6.00
CHEMBL141888 IC50 = 1584.89 nM 5.80
CHEMBL3138266 IC50 = 1584.89 nM 5.80
CHEMBL2069050 IC50 = 1584.89 nM 5.80
CHEMBL2068952 IC50 = 2511.89 nM 5.60
CHEMBL2068955 IC50 = 2511.89 nM 5.60
CHEMBL2069102 IC50 = 3162.28 nM 5.50
CHEMBL142270 IC50 = 3162.28 nM 5.50
CHEMBL3137944 IC50 = 6309.57 nM 5.20
CHEMBL2068954 IC50 = 10000.0 nM 5.00