Assay Detail

CHEMBL753102

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Binding affinity towards human Nicotinic acetylcholine receptor was determined using [3H]-cytisine

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Synthesis and nicotinic acetylcholine receptor in vivo binding properties of 2-fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine: a new positron emission tomography ligand for nicotinic receptors.

Doll F, Dolci L, Valette H, Hinnen F, Vaufrey F, Guenther I, Fuseau C, Coulon C, Bottlaender M, Crouzel C.
J Med Chem (1999) 42 : 2251 -2259
PubMed 10377231 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	10.32	10.32

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL308538	—	—	1	10.32

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL308538	—	Ki	=	0.048	nM	10.32