Assay Detail
Binding
CHEMBL753121
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity value against N-methyl-D-aspartate (NMDA) receptor using [3H]-CGS- 19755 in glutamate radioligand binding assay.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: identification of a potent, highly selective, and systemically-active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.99 | 5.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL323097 | — | — | 1 | 5.36 |
| CHEMBL431998 | — | — | 1 | 4.62 |
| CHEMBL34453 | — | — | 1 | - |
| CHEMBL103452 | — | — | 1 | - |
| CHEMBL40086 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL323097 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL431998 | — | IC50 | = | 23730.0 | nM | 4.62 |
| CHEMBL34453 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL103452 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL40086 | — | IC50 | > | 100000.0 | nM | - |