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Assay Detail

CHEMBL753140

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity for mouse opioid receptor kappa
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Kappa-type opioid receptor (CHEMBL4329)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Benzofuro[2,3-c]pyridin-6-ols: synthesis, affinity for opioid-receptor subtypes, and antinociceptive activity.
Hutchison AJ, de Jesus R, Williams M, Simke JP, Neale RF, Jackson RH, Ambrose F, Barbaz BJ, Sills MA.
J Med Chem (1989) 32 : 2221 -2226
PubMed 2549247 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 6.57 8.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL71301 1 8.22
CHEMBL592 LEVORPHANOL 4.0 1 8.00
CHEMBL555891 1 7.47
CHEMBL542881 1 6.72
CHEMBL542150 1 6.57
CHEMBL304616 1 6.47
CHEMBL302977 1 6.26
CHEMBL552619 1 5.82
CHEMBL72180 1 5.70
CHEMBL69559 1 5.58
CHEMBL544292 1 5.46
CHEMBL2114080 1 -
CHEMBL430441 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL71301 Ki = 6.0 nM 8.22
CHEMBL592 LEVORPHANOL Ki = 10.0 nM 8.00
CHEMBL555891 Ki = 34.0 nM 7.47
CHEMBL542881 Ki = 190.0 nM 6.72
CHEMBL542150 Ki = 270.0 nM 6.57
CHEMBL304616 Ki = 335.0 nM 6.47
CHEMBL302977 Ki = 550.0 nM 6.26
CHEMBL552619 Ki = 1500.0 nM 5.82
CHEMBL72180 Ki = 2000.0 nM 5.70
CHEMBL69559 Ki = 2600.0 nM 5.58
CHEMBL544292 Ki = 3500.0 nM 5.46
CHEMBL2114080 Ki > 5000.0 nM -
CHEMBL430441 Ki > 5000.0 nM -