Assay Detail
Binding
CHEMBL753141
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding ability towards opioid receptor kappa expressed in homogenates of rat brain.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Preparation and opioid activity of analogues of the analgesic dipeptide 2,6-dimethyl-L-tyrosyl-N-(3-phenylpropyl)-D-alaninamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.00 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL74791 | — | — | 1 | 8.00 |
| CHEMBL307595 | — | — | 1 | 6.55 |
| CHEMBL76527 | — | — | 1 | 6.48 |
| CHEMBL311145 | — | — | 1 | 6.42 |
| CHEMBL309491 | — | — | 1 | 5.89 |
| CHEMBL311352 | — | — | 1 | 5.27 |
| CHEMBL76816 | — | — | 1 | 5.23 |
| CHEMBL76062 | — | — | 1 | 5.10 |
| CHEMBL420562 | — | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL74791 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL307595 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL76527 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL311145 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL309491 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL311352 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL76816 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL76062 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL420562 | — | IC50 | = | 9300.0 | nM | 5.03 |