Assay Detail
Binding
CHEMBL753173
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of binding of [3H]U69, 593 to Opioid receptor kappa 1 in guinea pig membranes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
2002 Medicinal Chemistry Division Award address: monoamine transporters and opioid receptors. Targets for addiction therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.64 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19019 | NALTREXONE | 4.0 | 1 | 8.33 |
| CHEMBL10986 | — | — | 1 | 8.16 |
| CHEMBL300662 | — | — | 1 | 7.55 |
| CHEMBL50594 | — | — | 1 | 7.45 |
| CHEMBL52451 | — | — | 1 | 7.41 |
| CHEMBL51838 | — | — | 1 | 6.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19019 | NALTREXONE | Ki | = | 4.71 | nM | 8.33 |
| CHEMBL10986 | — | Ki | = | 6.91 | nM | 8.16 |
| CHEMBL300662 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL50594 | — | Ki | = | 35.8 | nM | 7.45 |
| CHEMBL52451 | — | Ki | = | 38.9 | nM | 7.41 |
| CHEMBL51838 | — | Ki | = | 122.0 | nM | 6.91 |