Assay Detail
Binding
CHEMBL753185
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against Opioid receptor kappa 1 was determined in brain membrane preparations from male Hartley guinea-pigs
7
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
C-alkylated spiro[benzofuran-3(2H),4'-1'-methyl-piperidine-7-ols] as potent opioids: a conformation-activity study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.26 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL300689 | — | — | 2 | 6.75 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 5.73 |
| CHEMBL607 | MEPERIDINE | 4.0 | 1 | - |
| CHEMBL50098 | — | — | 1 | - |
| CHEMBL431156 | — | — | 1 | - |
| CHEMBL297281 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL300689 | — | Ki | = | 177.0 | nM | 6.75 |
| CHEMBL300689 | — | Ki | = | 505.0 | nM | 6.30 |
| CHEMBL70 | MORPHINE | Ki | = | 1870.0 | nM | 5.73 |
| CHEMBL607 | MEPERIDINE | Ki | > | 100000.0 | nM | - |
| CHEMBL50098 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL431156 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL297281 | — | Ki | > | 100000.0 | nM | - |