Assay Detail
Functional
CHEMBL753316
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Inhibition of Forskolin-Stimulated Adenylyl Cyclase in CHO cells expressing Opioid receptor kappa 1
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Effects of the substitution of Phe4 in the opioid peptide [D-Ala8]dynorphin A-(1-11)NH2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.51 | 8.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL405057 | — | — | 1 | 8.91 |
| CHEMBL412228 | — | — | 1 | 8.45 |
| CHEMBL413832 | — | — | 1 | 8.28 |
| CHEMBL262310 | — | — | 1 | 7.53 |
| CHEMBL441198 | — | — | 1 | 7.44 |
| CHEMBL430081 | — | — | 1 | 7.33 |
| CHEMBL385696 | — | — | 1 | 7.14 |
| CHEMBL407084 | — | — | 1 | 6.29 |
| CHEMBL262838 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL405057 | — | EC50 | = | 1.24 | nM | 8.91 |
| CHEMBL412228 | — | EC50 | = | 3.56 | nM | 8.45 |
| CHEMBL413832 | — | EC50 | = | 5.2 | nM | 8.28 |
| CHEMBL262310 | — | EC50 | = | 29.4 | nM | 7.53 |
| CHEMBL441198 | — | EC50 | = | 36.5 | nM | 7.44 |
| CHEMBL430081 | — | EC50 | = | 46.9 | nM | 7.33 |
| CHEMBL385696 | — | EC50 | = | 72.4 | nM | 7.14 |
| CHEMBL407084 | — | EC50 | = | 515.0 | nM | 6.29 |
| CHEMBL262838 | — | EC50 | = | 573.0 | nM | 6.24 |