Assay Detail
Binding
CHEMBL753327
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity against Opioid receptor kappa 3 was determined by measuring the inhibition of [3H]NalBzoH binding to guinea pig cerebellar membranes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and opioid activity of [D-Pro10]dynorphin A-(1-11) analogues with N-terminal alkyl substitution.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.30 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384584 | — | — | 1 | 7.64 |
| CHEMBL406893 | — | — | 1 | 7.35 |
| CHEMBL268818 | — | — | 1 | 7.24 |
| CHEMBL266782 | — | — | 1 | 6.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384584 | — | Ki | = | 23.1 | nM | 7.64 |
| CHEMBL406893 | — | Ki | = | 44.4 | nM | 7.35 |
| CHEMBL268818 | — | Ki | = | 58.1 | nM | 7.24 |
| CHEMBL266782 | — | Ki | = | 113.0 | nM | 6.95 |