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Assay Detail

CHEMBL753354

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Functional
Inhibition of Plasmodium falciparum 3D7 in erythrocytes
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Expert

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy.
Martin MB, Grimley JS, Lewis JC, Heath HT, Bailey BN, Kendrick H, Yardley V, Caldera A, Lira R, Urbina JA, Moreno SN, Docampo R, Croft SL, Oldfield E.
J Med Chem (2001) 44 : 909 -916
PubMed 11300872 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 4.88 5.29

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL299988 1 5.29
CHEMBL56556 1 5.11
CHEMBL299491 1 4.25
CHEMBL55358 1 -
CHEMBL55140 1 -
CHEMBL417932 1 -
CHEMBL55214 NERIDRONIC ACID 3.0 1 -
CHEMBL434024 1 -
CHEMBL52761 1 -
CHEMBL301471 1 -
CHEMBL55359 1 -
CHEMBL55886 1 -
CHEMBL55812 OLPADRONIC ACID 2.0 1 -
CHEMBL293522 1 -
CHEMBL301247 1 -
CHEMBL834 PAMIDRONIC ACID 4.0 1 -
CHEMBL298771 1 -
CHEMBL870 ALENDRONIC ACID 4.0 1 -
CHEMBL923 RISEDRONIC ACID 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL299988 IC50 = 5100.0 nM 5.29
CHEMBL56556 IC50 = 7700.0 nM 5.11
CHEMBL299491 IC50 = 56700.0 nM 4.25
CHEMBL55358 IC50 > 200000.0 nM -
CHEMBL55140 IC50 > 200000.0 nM -
CHEMBL417932 IC50 > 200000.0 nM -
CHEMBL55214 NERIDRONIC ACID IC50 > 200000.0 nM -
CHEMBL434024 IC50 > 200000.0 nM -
CHEMBL52761 IC50 = 130000.0 nM -
CHEMBL301471 IC50 > 200000.0 nM -
CHEMBL55359 IC50 = 158000.0 nM -
CHEMBL55886 IC50 > 200000.0 nM -
CHEMBL55812 OLPADRONIC ACID IC50 > 200000.0 nM -
CHEMBL293522 IC50 > 200000.0 nM -
CHEMBL301247 IC50 > 200000.0 nM -
CHEMBL834 PAMIDRONIC ACID IC50 > 200000.0 nM -
CHEMBL298771 IC50 > 200000.0 nM -
CHEMBL870 ALENDRONIC ACID IC50 > 200000.0 nM -
CHEMBL923 RISEDRONIC ACID IC50 = 123000.0 nM -