Assay Detail
Binding
CHEMBL753420
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Binding affinity of compound was determined against Opioid receptor mu 1 from native receptor in guinea pig
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis, biological evaluation, and receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as kappa-opioid receptor agonists endowed with antinociceptive and antiamnesic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.69 | 8.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127828 | — | — | 1 | 8.71 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 8.52 |
| CHEMBL127969 | — | — | 1 | 8.19 |
| CHEMBL567175 | NALTRINDOLE | — | 1 | 7.83 |
| CHEMBL124015 | — | — | 1 | 7.16 |
| CHEMBL440765 | U-69593 | — | 1 | 5.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127828 | — | Ki | = | 1.93 | nM | 8.71 |
| CHEMBL70 | MORPHINE | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL127969 | — | Ki | = | 6.42 | nM | 8.19 |
| CHEMBL567175 | NALTRINDOLE | Ki | = | 14.7 | nM | 7.83 |
| CHEMBL124015 | — | Ki | = | 69.4 | nM | 7.16 |
| CHEMBL440765 | U-69593 | Ki | = | 1880.0 | nM | 5.73 |