Assay Detail
Binding
CHEMBL753435
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Inhibitory activity against opioid receptor mu of guinea pig brain using [3H]DAGO radioligand
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis, opioid receptor binding profile, and antinociceptive activity of 1-azaspiro[4.5]decan-10-yl amides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.27 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL592 | LEVORPHANOL | 4.0 | 1 | 9.22 |
| CHEMBL279065 | — | — | 1 | 8.70 |
| CHEMBL22211 | — | — | 1 | 8.20 |
| CHEMBL553991 | — | — | 1 | 7.92 |
| CHEMBL553782 | — | — | 1 | 7.80 |
| CHEMBL553062 | — | — | 1 | 7.77 |
| CHEMBL277202 | — | — | 1 | 7.68 |
| CHEMBL23016 | — | — | 1 | 6.82 |
| CHEMBL282244 | — | — | 1 | 6.68 |
| CHEMBL22569 | — | — | 1 | 6.66 |
| CHEMBL539228 | — | — | 1 | 6.26 |
| CHEMBL22458 | — | — | 1 | 6.24 |
| CHEMBL542069 | — | — | 1 | 6.22 |
| CHEMBL542564 | — | — | 1 | 5.66 |
| CHEMBL25386 | — | — | 1 | - |
| CHEMBL544684 | — | — | 1 | - |
| CHEMBL23777 | — | — | 1 | - |
| CHEMBL554212 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL592 | LEVORPHANOL | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL279065 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL22211 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL553991 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL553782 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL553062 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL277202 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL23016 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL282244 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL22569 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL539228 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL22458 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL542069 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL542564 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL25386 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL544684 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL23777 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL554212 | — | IC50 | > | 10000.0 | nM | - |