Assay Detail
Binding
CHEMBL753446
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Binding affinity against opioid receptor mu from guinea pig brain membranes using [3H]naloxone as radioligand
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Selective reversible and irreversible ligands for the kappa opioid receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.73 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118865 | SPIRADOLINE | 2.0 | 1 | 6.60 |
| CHEMBL73226 | — | — | 1 | 6.15 |
| CHEMBL290543 | — | — | 1 | 6.08 |
| CHEMBL70311 | — | — | 1 | 5.58 |
| CHEMBL307235 | — | — | 1 | 5.50 |
| CHEMBL73131 | — | — | 1 | 5.28 |
| CHEMBL74010 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118865 | SPIRADOLINE | Ki | = | 252.0 | nM | 6.60 |
| CHEMBL73226 | — | Ki | = | 702.0 | nM | 6.15 |
| CHEMBL290543 | — | Ki | = | 825.0 | nM | 6.08 |
| CHEMBL70311 | — | Ki | = | 2610.0 | nM | 5.58 |
| CHEMBL307235 | — | Ki | = | 3150.0 | nM | 5.50 |
| CHEMBL73131 | — | Ki | = | 5210.0 | nM | 5.28 |
| CHEMBL74010 | — | Ki | = | 13000.0 | nM | 4.89 |